The days of Ebola as an incurable disease may soon be a thing of the past

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The days of Ebola as an incurable disease may soon be a thing of the past, as Dr. Anthony Fauci, director of NIH’s National Institute of Allergy and Infectious Diseases rolls out the result of their latest research 

 

Monkey Study:
Ebola vaccine works, needs booster.
WASHINTON- New monkey studies shows that one shot of an experimental Ebola vaccine can trigger fast protection, but the effect waned unless the animal got a booster shot made a different way.
Some healthy people are rolling up their sleeves at the National Institute for the first human safety study of this vaccine in hopes it eventually might be used in the current Ebola outbreak in West Africa. The NIH on Sunday published some of the key animal research behind those injections. One reason the vaccine was deemed promising was that a single dose protected all four vaccinated monkeys when they were exposed to high levels of Ebola virus five weeks later, researchers reported in the journal Nature Medicine. Is five weeks fast enough? That’s in line with other vaccines routinely used today, and fortunately it didn’t take multiple doses to trigger that much protection, said Dr. Anthony Fauci, director of NIH’s National Institute of Allergy and Infectious Diseases, whose employees led the work.
The bigger challenge is that the protection wanes over time.
Researchers exposed monkeys to Ebola 10 months after vaccination, and this time only half were protected.
Partial protection is better than none, Fauci said. But the goal is long-lasting protection, so it was time to try booster shots. The vaccine is made with a chimpanzee cold virus, used as a delivery system for pieces of an Ebola gene. The researchers tried simply giving another dose as a booster two months later. That didn’t work well enough.
So they tried a different approach called “Primeboost.” The first dose, to prime the immune system, was that original chimp virus-based Ebola vaccine. But for the booster two months later, they made vaccine a different way. They incased the same Ebola gene pieces inside a poxvirus that’s used to make a vaccine against smallpox. (Neither vaccine type can cause Ebola.)
This time, all four monkeys still were protected 10 months after the initial shot.
With the Ebola crises rapidly worsening, the World Health Organization said Friday it would try to speed the use of certain experimental products, including two vaccine candidates. The WHO said that in November, it expects early results from first-stage studies to see if the vaccine appears safe and trigger an immune reaction in people.
That would help the shots’ effectiveness in health care worker in West Africa.
Small animal and human safety studies cannot guarantee that experimental vaccines really work in an outbreak, Fauci said.
That’s why he emphasizes public health workers, using personal protection equipment.
“Make sure people do what works,” he said. The booster-shot findings illustrate an added complexity to speeding an experimental first phase study results would shed light only on that “priming” vaccine made from the chimp cold virus, Fauci said. The proxvirus booster step would be tested later only if scientists decided the initial vaccine was promising enough.
Still, manufacturer GlaxcoSmithKline has said it plans to begin manufacturing up to 10,000 doses of the initial NIH-developed vaccine. Canadian researcher created similar Ebola vaccine that works in Monkeys. Manufacturer NewLink Genetics of Ames Iowa said first-stage safely testing in healthy volunteers is set to begin in few weeks.


Source: The Times Herald

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